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KMID : 1157520140100010009
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International Journal of Clinical Preventive Dentistry
2014 Volume.10 No. 1 p.9 ~ p.14
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The Inhibition Effects of Cetylpyridinium Chloride in Dentifrices on Plaque Formation: Clinical Test
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Yoo Chang-Seon
Chae Sang-Kyun
Lee Hyun-Gee
Kim Chan-Ho
Kim Dae-Kyeong
Kim Wang-Gi
Kim Ki-Eun
Ahn Hyo-Kwang
Kim Ji-Eun
Oh Yoon-Jong
Yoo Su-Min
Ahn Geum-Sun
Hwang Kyung-Suk
Kwon Ha-Jeong
Park Yong-Duk
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Abstract
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Objective: Various kinds of anti-plaque agents are mixed to dentifrices in order to prevent oral diseases. This study is to evaluatethe efficacy on plaque index and safety of dentifrice containing cetylpyridinium chloride by in vitro test and clinical test.
Methods: Streptococcus mutans (KCTC3065) was incubated for 24 hours. After mucin treatment of hydroxyapatite disks, opticaldensity measurement was performed at 590 nm to compare anti-plaque effects. Clinical tests was performed by doubleblind test after using control dentifrice for 2 weeks and setting baseline to 40 of Korean adults. The oral hygiene index wasinvestigated during the use of control and experimental dentifrices samples twice-daily for 12 weeks.
Results: In vitro test showed the anti-plaque efficacy of experimental group was significantly increased 54.3% than controlgroup (p＜0.05). In addition, in vivo test shows the O’Leary plaque index of experimental group were improved 53.6% thancontrol group (p＜0.05), and the persons’ effect ratio was 80.0% (p＜0.05).
Conclusion: Cetylpyridinium chloride in dentifrice significantly inhibited the growth of dental plaque and advanced the oralhygiene index.
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KEYWORD
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dental plaque, cetylpyridinium, dentifrices, glycyrrhizinic acid
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